HM 355S

A fully automated microtome with four mechanized cutting modes to deliver exceptional sections across an extensive range of specimen types. Choice of manual or mechanized sectioning. Single, multiple, interval and continuous cutting modes for optimum control according to sectioning requirements. Unique “double-tap” startup and emergency stop features enhance user safety.

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Section safely with excellent quality.

Microtomes from Epredia are designed to be precise and stable, helping to yield superior sectioning results for even the most difficult-to-cut paraffin sections.



  • Menu-driven control panel can be used on either side of instrument
  • Display monitors a range of functions including cutting speed, section count, section thickness, and advance distance
  • Four cutting modes of operation (single, interval, multi and continuous)
  • User-selected cutting window control maximizes throughput by allowing the return stroke to be faster than the optimized cutting stroke
  • Manual and/or foot pedal control
  • Double tap start activates sectioning motor
  • One-handed zero-orientation head
  • Joy-stick control specimen advance and rewind
  • Emergency stop immediately cuts power to the motor
  • Five languages available for viewing commands
  • Large, easy-to-clean waste tray extends below the blade holder


  • Excellent for routine paraffin sections and plastic-embedded specimens
  • High-quality sections with less fatigue
  • Unmatched safety, ease-of-use, reliability, and consistency of results
  • Instant switch between trim and section settings with independently selectable trim and section speeds
  • Rock option: specimen head advances by a set amount to trim specimens without turning the hand wheel through full turns
  • Selectable retraction feature
  • Guide-rail guidance


  • Cutting stroke: 72 mm
  • Total specimen advance: 28 mm
  • Maximum sectioning speed: 400 mm/s
  • Section thickness range: 0.5-100 μm
  • Trim thickness range: 5-500 μm
  • Retraction range: 40 μm
  • Section counter: Standard
  • Dimensions (D x W x H): 20.5 x 16 x 11 in. (52 x 41 x 28 cm)
  • Weight: 77 lb. (35 kg)


  • Standard tools
  • Brushed aluminum cover plate
  • Dust cover
  • Instruction manual
  • 905200 includes microtome only
  • 905200A includes microtome, universal cassette clamp (715020S) and disposable blade carrier E (705800)
  • 905200ER includes microtome, universal cassette clamp (715020S) and disposable blade carrier ER (705830)

Brochure - HM 355S

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Brochure - Epredia Microtomy Solutions

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